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. Author manuscript; available in PMC: 2015 Jan 8.
Published in final edited form as: J Am Chem Soc. 2013 Dec 18;136(1):291–298. doi: 10.1021/ja409824b

Table 3.

Substrate scope for the asymmetric hydrogenation of allylic sulfoxides

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Entrya R PH2 (atm) t (h) yield 3 (%) ee 3 (%)
1 2-CO2Me (1a) 0.1 48 73 88
2 H (1b) 0.1 48 65 50
3 2-CO2tBu (1c) 0.1 48 69 84
4 2-CO2nC6H13 (1d) 0.1 48 84 86
5 2-NO2 (1e) 1 24 55 72
6b 2-CF3 (1f) 0.1 48 53 88
a

Full substrate conversion was achieved in all cases.

b

4 mol % Rh-catalyst used