Representative histological sections of samples stained with hematoxylin and eosin 3 weeks post-operatively at ×1.25 magnification. Group (A), (B) and (C), represents cranial defects implanted with 0, 50 and 90 wt% MCP gelatin sponges, without BMP-2, respectively. Group (a), (b) and (c), represents cranial defects implanted with 0, 50 and 90 wt% MCP gelatin sponges containing BMP-2, respectively. Black arrows refer to the borders of the defect site