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Effect of bufalin on carrageenan-induced rat paw edema. (a) Chemical structure of bufalin. (b) Bufalin at doses of 0.15, 0.3, and 0.6 mg/kg, the reference drug indomethacin at 10 mg/kg, and the vehicle were administered to rats 30 min before carrageenan injection. The percentage of increase in paw volume of the right hind paws of each rat at each time point was calculated. Data are expressed as the mean ± S.E.M. (n = 8), P value, compared with the vehicle group.
