(b)
| Change in GFR (mL/min/1.73 m2) after conversion | Change in serum creatinine concentration (µm/L) after conversion | Change in 24 h CrCl (mL/min) after conversion | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 mo | 6 mo | 1 year | 2 years | 3 years | 1 mo | 3 mo | 6 mo | 1 year | 2 years | 3 years | 3 mo | 1 year | |
| Early conversion (≤3 months after transplantation) | |||||||||||||
| McKenna et al. ILTS. 2011 (Abstract O-17) [68] | |||||||||||||
| Rogers et al. Clin Transplant. 2009; 23: 887–96 [48] | +29.7 versus +18.5 (early versus late conversion, P < 0.05) | +28.7 versus +12.4 (early versus late conversion, P < 0.05) | +25.5 versus +14.7 (early versus late conversion, P < 0.05) | ||||||||||
| Harper et al. Transplantation. 2011; 91: 128–32 [67] | +10.6 versus baseline (P < 0.05) | ||||||||||||
| Schleicher et al. Transplant Proc. 2010; 42: 2572–5 [49] | +15 versus +9 (early versus late conversion, P = 0.04) | +16 versus +10 (early versus late conversion, P = 0.05) | +22† versus +12† (early versus late conversion, P = 0.04) | −0.7‡ (early conversion versus baseline, P = 0.01) −0.6‡ (late conversion versus baseline, P = 0.05) |
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|
| |||||||||||||
| Late conversion (>3 months after transplantation) | |||||||||||||
| Campbell et al. Clin Transplant. 2007; 21: 377–84 [71] | 0‡ (SRL versus CNI) | ||||||||||||
| Di Benedetto et al. Transplant Proc. 2009; 41: 1297–9 [81] | |||||||||||||
| DuBay et al. Liver Transpl. 2008; 14: 651–9 [72] | |||||||||||||
| Herlenius et al. Transplant Proc. 2010; 42: 4441–8 [73] | +12 versus baseline (P = 0.03) | ||||||||||||
| Lam et al. Dig Dis Sci. 2004; 49: 1029–35 [74] | −0.32‡ versus baseline (P = 0.029) | +0.12‡, versus baseline (P = NS) | |||||||||||
| Sanchez et al. Transplant Proc. 2005; 37: 4416–23 [69] | +8.2, P = 0.05 versus case control | +20.2, NS versus case control | +16.1, NS versus case control | −0.1 | 0 | 0 | |||||||
| Shenoy et al. Transplantation. 2007; 83: 1389-92 [76] | +12 versus −4, NS versus CNI | ||||||||||||
| Uhlmann et al. Exp Clin Transplant. 2012; 10: 30–8 [77] | +11.9 versus baseline (P < 0.05) | −27 versus baseline (P < 0.05) | |||||||||||
| Watson et al. Liver Transpl. 2007; 13: 1694–702 [78] | +7.7 versus baseline (P = 0.001) | +6.1 versus baseline (P = 0.024) | |||||||||||
| Abdelmalek et al. Am J Transplant. 2012; 12: 694–705 [45] | −4.45 versus −3.07 (SRL versus CNI, P = 0.34) | ||||||||||||
| Bäckman et al. Clin Transplant. 2006; 20: 336–9 [82] | +6.4 (P = NS from baseline) | ||||||||||||
| Fairbanks et al. Liver Transpl. 2003; 9: 1079–85 [83] | +9* versus baseline (P = 0.01) |
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| Nair et al. Liver Transpl. 2003; 9: 126–9 [84] | −0.45‡ versus baseline (P = 0.001) | ||||||||||||
| Neff et al. Transplant Proc. 2003; 35: 3029–31 [85] | +11.3 versus baseline | ||||||||||||
| Vivarelli et al. Transplant Proc. 2010; 42: 2579–84 [80] | +18 versus baseline† | +19 versus baseline† | +19 versus baseline† | ||||||||||
| Wadei et al. Transplantation. 2012; 93: 1006–12 [86] | +3.5† versus baseline (P = 0.03) | −0.1 versus baseline (P = 0.25) | |||||||||||
P values are included where available.
*Median eGFR, mean of 67 weeks; †mL/min; ‡mg/dL.
CNI: calcineurin inhibitor; CrCl: creatinine clearance; GFR: glomerular filtration rate; mo: month; NS: nonsignificant; SRL: sirolimus.