Table 2.
Relative gene expression of ANXA1 and LGALS1 mRNA in the intestinal metaplasia (IM) and gastric ulcer (GU) groups and comparison according to risk factors.
| Variables | ANXA1 | LGALS1 | ||||||
|---|---|---|---|---|---|---|---|---|
| IM | GU | IM | GU | |||||
| (N = 36) | (N = 29) | (N = 36) | (N = 29) | |||||
| mRNA | ||||||||
| Mean ± SD | 6.22 ± 1.43 | 6.69 ± 1.56 | 0.35 ± 1.37 | 0.69 ± 1.65 | ||||
| (range) | (2.55–8.90) | (2.42–8.80) | (−3.54–2.86) | (−4.04–3.13) | ||||
| P | 0.21 | 0.38 | ||||||
| Age (years) | ||||||||
| <60 | 16 (44.5%) | <55 | 15 (51.7%) | <60 | 16 (44.5%) | <55 | 15 (51.7%) | |
| (Mean ± SD) | 6.48 ± 1.55 | 6.81 ± 1.71 | 0.62 ± 1.11 | 0.63 ± 1.84 | ||||
| ≥60 | 20 (55.5%) | ≥55 | 14 (48.3%) | ≥60 | 20 (55.5%) | ≥55 | 14 (48.3%) | |
| (Mean ± SD) | 6.00 ± 1.32 | 6.55 ± 1.43 | 0.14 ± 1.53 | 0.76 ± 1.50 | ||||
| P | 0.34 | 0.66 | 0.28 | 0.83 | ||||
| Gender | ||||||||
| Female | 19 (52.8%) | 8 (27.6%) | 19 (52.8%) | 8 (27.6%) | ||||
| (Mean ± SD) | 6.30 ± 1.34 | 7.07 ± 1.18 | 0.80 ± 1.30 | 1.41 ± 1.26 | ||||
| Male | 17 (47.2%) | 21 (72.4%) | 17 (47.2%) | 21 (72.4%) | ||||
| (Mean ± SD) | 6.12 ± 1.55 | 6.54 ± 1.69 | −0.15 ± 1.29 | 0.42 ± 1.73 | ||||
| P | 0.71 | 0.35 | 0.03* | 0.11 | ||||
| Drinking | ||||||||
| Yes | 10 (27.8%) | 11 (39.3%) | 10 (27.8%) | 11 (39.3%) | ||||
| (Mean ± SD) | 6.12 ± 1.26 | 6.17 ± 1.97 | −0.13 ± 1.75 | 0.29 ± 1.81 | ||||
| No | 26 (72.2%) | 17 (60.7%) | 26 (72.2%) | 17 (60.7%) | ||||
| (Mean ± SD) | 6.26 ± 1.51 | 7.10 ± 1.17 | 0.54 ± 1.17 | 0.88 ± 1.58 | ||||
| P | 0.78 | 0.18 | 0.29 | 0.39 | ||||
| Smoking | ||||||||
| Yes | 26 (72.2%) | 18 (64.3%) | 26 (72.2%) | 18 (64.3%) | ||||
| (Mean ± SD) | 6.26 ± 1.49 | 6.66 ± 1.64 | 0.29 ± 1.49 | 0.46 ± 1.88 | ||||
| No | 10 (27.8%) | 10 (35.7%) | 10 (27.8%) | 10 (35.7%) | ||||
| (Mean ± SD) | 6.11 ± 1.32 | 6.86 ± 1.52 | 0.53 ± 1.01 | 0.98 ± 1.21 | ||||
| P | 0.76 | 0.75 | 0.58 | 0.39 | ||||
| H. pylori | ||||||||
| Positive | 14 (38.9%) | 15 (55.5%) | 14 (38.9%) | 15 (55.5%) | ||||
| (Mean ± SD) | 6.70 ± 1.75 | 6.88 ± 1.35 | 0.29 ± 1.61 | 0.94 ± 1.59 | ||||
| Negative | 22 (61.1%) | 12 (44.5%) | 22 (61.1%) | 12 (44.5%) | ||||
| (Mean ± SD) | 5.91 ± 1.11 | 6.47 ± 1.86 | 0.39 ± 1.23 | 0.67 ± 1.77 | ||||
| P | 0.15 | 0.53 | 0.85 | 0.69 | ||||
| Genotype cagA a | ||||||||
| Positive | 12 (85.7%) | 10 (66.7%) | 12 (85.7%) | 10 (66.7%) | ||||
| (Mean ± SD) | 6.88 ± 1.81 | 6.82 ± 1.60 | 0.45 ± 1.58 | 0.50 ± 1.68 | ||||
| Negative | 2 (14.3%) | 5 (33.3%) | 2 (14.3%) | 5 (33.3%) | ||||
| (Mean ± SD) | 5.58 ± 0.96 | 6.99 ± 0.81 | −0.62 ± 2.12 | 1.81 ± 1.03 | ||||
| P | 0.20 | 0.77 | 0.55 | 0.16 | ||||
aNonparametric Mann-Whitney test; *significant difference.