Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Main pathways activated during hyperglycaemia and low insulin level that alter the modulation of vascular tone, reducing nitric oxide, and increasing endothelin-1 release and so lead to endothelial dysfunction and diabetes-associated vascular disease. Cav-1: caveolin-1, eNOS: endothelial nitric oxide synthase; ET-1: endothelin-1; NO: nitric oxide.
