Figure 4.

Neuroprotective effect of MK801 in rats anesthetized with chloral hydrate (CHLO) or isoflurane (ISO). (a) Representative brain slices after Nissl staining for each group treated with vehicle (VEH) or MK801 (MK801). (b) Infarct volumes (corrected from oedema) were determined after one-hour MCAO followed by 23 hours of reperfusion period. MK801 was injected three minutes before MCAO (IV, 0.5 mg/kg). Volumes are expressed in mm³ (mean ± SEM); n = 8 animals per group. Differences in infarct volume were significant according to one-way ANOVA test (P < 0.05).