Figure 3.

Target profile of the affinity probes tested. Left panel: Bars represent the average log2 bound/competed ratio of protein hits found in one of the competition experiments. Compounds tested are shown in bold numbers (1, 4–8). Proteins listed were quantified in our experiments with significant H/L-ratios and p-value <0.05 (Student´s t-Test). Right panel: Heat map of the sequence coverage obtained for specific hits found in this study. †: not quantified in one of the four experiments. ‡: Single experimental outlier raises H/L-ratio p-value above the <0.05 threshold.