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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Oncogene. 2012 Nov 26;32(42):5017–5025. doi: 10.1038/onc.2012.534

Figure 6. Tip60 null condition favors viral DNA synthesis.

Figure 6

(A) Tip60 knockdown increases viral DNA production. Viral DNA copy number was measured in MCF10A cells infected with dl309 strain and treated with control siGL2 or siTip60 at 72 hrs post infection. Mean ± SD (n=3).

(B) Tip60 HAT activity is required for suppression of viral DNA titer. MCF10A cell line stably over-expressing either wild Tip60 or catalytically dead Tip60 or stably transfected with vector alone were infected with dl309 strain and viral DNA copy number was measured at 72 hrs post infection as in (A). Mean ± SD (n=3).