Table 1.
Clinical trials combining HDACIs with radiation therapy.
| Clinical Trial No | Title | Sponsor |
|---|---|---|
| NCT00946673 | A Phase I Trial of Vorinostat Concurrent With Stereotactic Radiotherapy in Treatment of Brain Metastases From Non-Small Cell Lung Cancer |
Stanford University |
| NCT00983268 | Phase I Trial of Chemoradiation With Capecitabine and Vorinostat in Pancreatic Cancer. |
Vanderbilt-Ingram Cancer Center |
| NCT00731731 | Phase I/II Study of Vorinostat (Suberoylanilide Hydroxamic Acid [SAHA]), Temozolomide, and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma |
National Cancer Institute (NCI) |
| NCT01236560 | A Randomized Phase II/III Study of Vorinostat and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab and Local Irradiation Followed by Maintenance Bevacizumab and Temozolomide in Children With Newly Diagnosed High-Grade Gliomas |
National Cancer Institute (NCI) |
| NCT01189266 | A Phase I-II Study of Suberoylanilide Hydroxamic Acid (SAHA, Vorinostat) and Local Irradiation, Followed by Maintenance SAHA in Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG) |
National Cancer Institute (NCI) |
| NCT01064921 | A Phase I Trial of Vorinostat in the Treatment of Advanced Oropharyngeal Carcinoma of the Head and Neck |
Ohio State University Comprehensive Cancer Center |
| NCT00831493 | Phase I/II Trial of Vorinostat and Radiation Therapy in Patients With Locally Advanced Pancreatic Cancer |
M.D. Anderson Cancer Center |
| NCT00662311 | Phase I/II Clinical Trial Evaluating the Use of Vorinostat Combined With Paclitaxel and Radiotherapy in Patients With Inoperable Stage III Non-Small Cell Lung Cancer Unable to Tolerate Cisplatin |
Fred Hutchinson Cancer Research Center |
| NCT01378481 | High-Dose Vorinostat With Radiation Therapy in the Treatment of Recurrent Glioma |
Thomas Jefferson University |
| NCT00838929 | Phase I Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases |
Thomas Jefferson University |
| NCT00404326 | A Phase II Study of Transcriptional Therapy With the DNA Demethylating Hydralazine and the HDAC Inhibitor Valproate Associated to Concomitant Cisplatin Chemoradiation in FIGO Stage III Cervical Cancer. |
National Institute of Cancerología |
| NCT01384799 | A Phase I Dose Escalation Study to Investigate the Safety and Pharmacokinetics of Intravenous CUDC- 101 With Concurrent Cisplatin and Radiation Therapy in Subjects With Locally Advanced Human Papillomavirus Negative Head and Neck Cancer |
Curis, Inc. |
| NCT00455351 | Phase I Study on Suberoylanilide Hydroxyamic Acid (Vorinostat) a Histone Deacetylase Inhibitor, in Palliative Radiotherapy for Advanced Tumors. |
Oslo University Hospital |
| NCT00302159 | A Phase II Clinical Trial of the Histone Deacetylase Inhibitor Valproic Acid in Combination With Temodar and Radiation Therapy in Patients With High Grade Gliomas: Multi-Institutional Trial |
National Institutes of Health Clinical Center (CC) |
| NCT00948688 | Phase 1/2 Study of Vorinostat in Combination With Radiation Therapy and Infusional 5-FU in Patients With Locally Advanced Adenocarcinoma of the Pancreas |
Massachusetts General Hospital |
| NCT00437957 | Phase I Trial Of Temozolomide Combined With The Histone Deacetylase Inhibitor Valproic Acid (VPA) And Whole Brain Radiation Therapy (WBR) For Brain Metastases From Solid Tumors In Adults |
H. Lee Moffitt Cancer Center and Research Institute |
| NCT00821951 | A Dose Escalation Study of Vorinostat in Combination With Palliative Radiotherapy for Patients With Non- Small Cell Lung Cancer |
Yale University |