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The procedure includes: 1) esterifying –OH groups with azido-acetic acid in the presence of EDC and DMAP; 2) deprotection of Boc groups by 2, 2, 2-trifluoroacetic acid; 3) click coupling of –N3 groups with Thy-yne under CuBr and PMDETA; 4) amidation of –NH2 groups with azido-acetic acid in the presence of EDC and DMAP; 5) click coupling of –N3 groups with Ade-yne under CuBr and PMDETA.
