Table 3. Meta-analysis of Apolipoprotein E gene polymorphism in Alzheimer's disease.

	Fix-effect model				Random-effect model
	OR (95% CI)	P	Ph	I2	OR (95% CI)	P	Ph	I2
Allele
ApoE ε2	0.88 (0.73, 1.07)	0.20	0.0002	61%	0.93 (0.66, 1.29)	0.65	0.0002	61%
ApoE ε3	0.42 (0.37, 0.47)	<0.00001	0.07	34%	0.42 (0.36, 0.49)	<0.00001	0.07	34%
ApoE ε4	3.93 (3.37, 4.58)	<0.00001	0.81	0%	3.89 (3.33, 4.54)	<0.00001	0.81	0%
Genotype
ApoE ε4/ε4	11.71 (6.38, 21.47)	<0.00001	0.98	0%	9.84 (5.28, 18.34)	<0.00001	0.98	0%
ApoE ε3/ε3	0.39 (0.33, 0.45)	<0.00001	0.25	16%	0.38 (0.33, 0.45)	<0.00001	0.25	16%
ApoE ε2/ε2	1.06 (0.55, 2.06)	0.86	0.60	0%	1.09 (0.52, 2.27)	0.83	0.60	0%
ApoE ε4/ε3	3.08 (2.57, 3.69)	<0.00001	0.06	35%	3.16 (2.48, 4.02)	<0.00001	0.06	35%
ApoE ε3/ε2	0.67 (0.53, 0.85)	0.0008	0.18	23%	0.66 (0.49, 0.88)	0.005	0.18	23%
ApoE ε4/ε2	2.10 (1.35, 3.26)	0.001	0.32	11%	1.92 (1.13, 3.28)	0.02	0.32	11%

P_h, P_{heterogeneity}.