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. 2014 Mar 17;7:17. doi: 10.3389/fnmol.2014.00017

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Copyright © 2014 Duda, Pertzev and Sharma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Topography of ANF-RGC. The dashed lines on the right show the boundaries of: LS, leader sequence; ExtD, extracellular domain; TM, transmembrane domain; ICD, intracellular domain. The functional domains in ICD, their names and the aa constituting their boundaries are indicated at the left: JMD, juxtamembrane domain; ARM, the ATP regulated module; SHD-signaling helix domain; CCD-core catalytic domain. The site targeted by NCδ (encircled) is within CCD. (B) The signaling pathways of ANF and of NCδ are independent. The trajectory of the ANF pathway is in red dashed arrow. From the ExtD, it passes through the TM, ARM and SHD in its course to CCD. The trajectory of the NCδ pathway (in blue dashed arrow) is within the CCD. The CCD exists as an antiparallel homodimer (reproduced with permission from ref. Duda et al., 2012b).