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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Ann Surg Oncol. 2013 Jul 31;20(12):3862–3868. doi: 10.1245/s10434-013-3168-2

Figure 3. Growth suppression of medullary thyroid cancer cells (MTC-TT) by MK-2206 is mediated by apoptosis.

Figure 3

Treatment of MTC-TT cells with MK-2206 (0–10 µM) for four days resulted in increased expression of apoptotic proteins cleaved poly-ADP ribose polymerase (PARP) and cleaved caspase-3, with corresponding decrease in apoptosis inhibitor survivin. Stable cyclin D1 levels suggest there is no associated change in cell cycle signaling. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was used as a loading control.