TABLE 6.
Differences between primary sclerosing cholangitis and immunoglobulin (Ig)G4 cholangiopathy
| Feature | Primary sclerosing cholangitis | IgG4 cholangiopathy or autoimmune cholangiopathy |
|---|---|---|
| Age | Young to middle age | Older |
| Obstructive jaundice | Marked | Less severe |
| Biliary strictures | Band-like strictures with beaded and pruned tree appearance | Segmental strictures (distal CBD) |
| Associated autoimmune pancreatitis | No | Yes |
| IgG4-related diseases | No | Yes |
| IBD association | Yes | Rarely associated with type 2 AIP |
| Risk of cholangiocarcinoma | Yes | Rare (with limited data), can mimic |