Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Key signaling elements in the differentiation of enteroendocrine cells. Enteroendocrine cells are derived from gut epithelial stem cell lineage in which Wnt signaling, via the LGR5 receptor, activates Notch negative progenitor cells. These ultimately become secretory cells at maturation. By contrast, Notch positive progenitor cells follow a differentiation pathway that maintains absorptive capacity in the gastrointestinal lumen.
