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. 2014 Feb 25;111(10):3817–3822. doi: 10.1073/pnas.1312436111

Fig. 7.

Fig. 7.

Specific inhibition of 11βHSD1 corrects uremia-induced insulin resistance in adenine-fed rats. Experimental uremia was induced in rats by Ad (n = 8 per group). UE2316 (20 mg⋅kg−1⋅d−1) or vehicle was administered by osmotic minipump for 2 wk. (A) plasma glucose response to 2 g per kg dextrose injected i.p. (GTT) and (B) plasma glucose response to 2 units per kg of body weight porcine insulin injected i.p. (ITT). Data are expressed as mean ± SEM. Statistically significant differences between CON and Ad are indicated by ***P < 0.001. Statistically significant effects of CBX treatment are indicated by #P < 0.05, ##P < 0.01, and ###P < 0.001.