Fig. 1.

Identification of lst-1 and sygl-1 as candidate GSC regulators. (A) DTC (red) uses GLP-1/Notch signaling to maintain GSCs within the niche. Asterisk marks distal end. (B) Fifteen genes (asterisk) are shared between lists of putative Notch and FBF targets. Double RNAi of two common genes, lst-1 and sygl-1, caused a Glp phenotype. Also see Tables S1 and S2. (C) lst-1 and sygl-1 genes. Yellow, exons; red lines, LAG-1 binding sites (LBS); black bar, deletions; purple line, probe for in situ hybridizations (exons only). (D) LST-1 and SYGL-1 proteins and their predicted motifs.