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Exposure conditions in CD-DST.
| Drug | Concentration (μg/ml) | Exposure time (h) | Clinical dose (mg/m2) | AUC (in vitro/human)a |
|---|---|---|---|---|
| ADM | 0.02 | 24 | 60 | 0.98 |
| EPI | 0.1 | 24 | 40 | 1.20 |
| DOC | 0.1 | 24 | 60 | 0.83 |
| PTX | 1.0 | 24 | 210 | 1.03 |
1.0, same as clinical AUC. ADM, adriamycin; EPI, epirubicin; DOC, docetaxel; PTX, paclitaxel; AUC, area under the drug concentration-time curve.
