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Detection of pro-caspase-3 as a typical apoptosis marker by Human Apoptose Array kit. Besides other cell markers (data not shown) we detected the typical apoptosis marker pro-caspase-3 in nine different squamous carcinoma cell lines treated with BI2536 in combination with cisplatin and docetaxel. Fig. 2 shows the results received when treating PE/CA-PJ 49 cells with BI2536 in combination with cisplatin and docetaxel.
