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. Author manuscript; available in PMC: 2014 Mar 17.
Published in final edited form as: Expert Rev Vaccines. 2013 Sep;12(9):1033–1045. doi: 10.1586/14760584.2013.825454

Table 1.

Clinical trials evaluating Salmonella–vectored vaccine strains.

Serovar Strain Attenuating
mutations		 Antigen Plasmid
stabilization		 Antigen gene
promoter		 Study type Reference
Typhi TSB7 ΔaroC ΔssaV LT-B Not applicable PssaG Open label [79]
Typhi χ9639(pYA4088) RpoS− and footnote 1 PspA AsdA+ Ptrc regulated Double blind [102]
Typhi χ9640(pYA4088) RpoS+ and footnote 1 PspA AsdA+ Ptrc regulated Double blind [102]
Typhi χ9633(pYA4088) RpoS+ and footnote 2 PspA AsdA+ Ptrc regulated Double blind [102]
Typhi CVD908-htrA ΔaroC ΔaroD htrA thyA OprF-OprI ThyA+ Pyz Not reported [87]
Typhi CVD908-htrA ΔaroC ΔaroD htrA thyA OprF-OprI ThyA+ PpagC Not reported [87]
Typhi Ty21a galE thyA Vi− Multiple mutations OprF-OprI ThyA+ Pyz Not reported [87]
Typhi Ty21a galE thyA Vi− Multiple mutations OprF-OprI ThyA+ PpagC Not reported [87]
Typhi Ty21a galE thyA Vi− Multiple mutations Urease ThyA+ Undescribed constitutive promoter Double blind [86]
Typhi Ty21a galE thyA Vi− Multiple mutations HP0231 ThyA+ Undescribed constitutive promoter Double blind [86]
Typhi VXM01 (Ty21a) galE thyA Vi− Multiple mutations VEGFR-2 Not described CMV Double blind [89]
Typhimurium SalpIL2 Δcya Δcrp ΔasdA Human IL-2 AsdA+ Ptrc constitutive Open label [103]
1

ΔPcrp527:TT araC PBADcrp ΔPfur81:TT araC PBADfur Δpmi-2426 Δ (gmd-fcl)-26 ΔsopB1925 ΔrelA198:araC PBADlacI TT ΔaraE25 ΔtviABCDE10 ΔagfBAC811 ΔasdA33

2

ΔPcrp527:TT araC PBADcrp ΔPfur81:TT araC PBADfur Δpmi-2426 Δ(gmd-fcl)-26 ΔsopB1925 ΔrelA198:araC PBADlacI TT ΔaraE25 ΔaraBAD 23 ΔtviABCDE10 ΔagfBAC811 ΔasdA33