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. Author manuscript; available in PMC: 2014 Mar 17.
Published in final edited form as: Science. 2012 Mar 23;335(6075):1513–1516. doi: 10.1126/science.1214985

Figure 4. Memory performance during synthetic reactivation is network specific.

Figure 4

A) When CNO induced synthetic activation does not occur in identical neural populations during memory formation and memory retrieval, a memory deficit is observed. hM3Dfos mice show significantly less freezing than control mice in ctxB both in the absence and presence of CNO. hM3Dfos n = 14, control = 17. Repeated measures ANOVA main effect of genotype F(1, 23) = 51.15, p < 0.001. B) When hM3Dqfos mice are exposed to ctxB off of dox to induce hM3Dq expression and then fear conditioned on dox after CNO injection in ctxB, synthetic activation by CNO is not necessary for memory recall in ctxB. ctxB: hM3Dqfos n = 9, control n = 10, ctxBcno: hM3Dqfos n = 5, control n = 6. Repeated measures ANOVA F(2, 18) = 0.0474, p = 0.954.