Table 2.
Mean doses in Gy (range) from the boost treatment of 30.6 Gy (23.4–54 Gy) for each treatment technique and margin
| Treatment technique | 3D CRT |
IMRT |
PT |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target/risk organ | PTV A | PTV B | PTV C | PTV D | PTV A | PTV B | PTV C | PTV D | PTV A | PTV B | PTV C | PTV D |
| Hippocampus, boost dose | 14.3 (0.4–25.5) | 18.0 (0.7–28.1) | 20.6 (1.1–28.9) | 25.9 (17.0–29.4) | 6.9 (2.2–13.8) | 9.5 (2.4–15.8) | 11.8 (2.7–20.9) | 14.4 (9.9–22.3) | 3.3 (0.0–8.6) | 6.1 (0.0–12.8) | 8.7 (0.0–17.9) | 11.4 (7.9–17.6) |
| Hippocampus, total dose* | 36.6 (22.7–47.7) | 40.2 (23.0–50.3) | 42.8 (23.3–51.1) | 48.2 (39.3–51.7) | 24.4 (18.5–32.2) | 27.0 (18.7–34.3) | 29.3 (18.9–39.3) | 31.9 (26.2–40.8) | 10.5 (2.7–17.8) | 13.3 (2.7–22.0) | 15.9 (2.7–27.1) | 18.6 (10.7–26.7) |
| Cochlea | 17.9 (0.7–28.6) | 22.0 (1.1–30.0) | 24.9 (2.0–30.0) | 30.2 (29.2–31.3) | 11.6 (4.0–18.4) | 14.8 (5.6–20.7) | 17.8 (8.3–23.7) | 24.2 (21.0–27.6) | 4.9 (0.0–15.5) | 10.0 (0.0–19.8) | 14.3 (0.0–22.2) | 19.3 (16.3–22.8) |
| Pituitary gland | 2.9 (0.3–6.6) | 5.9 (0.5–15.3) | 10.4 (0.7–24.7) | 17.9 (1.0–29.0) | 8.4 (1.1–18.3) | 10.8 (1.4–25.4) | 12.5 (1.7–27.0) | 15.1 (1.0–29.4) | 0.6 (0.0–9.2) | 1.0 (0.0–10.8) | 3.3 (0.0–20.1) | 10.5 (0.3–28.0) |
| Eyes | 0.6 (0.0–5.4) | 0.7 (0.1–5.9) | 0.9 (0.1–7.0) | 1.3 (0.4–7.3) | 1.9 (0.5–3.8) | 2.4 (0.7–4.6) | 2.9 (0.8–5.5) | 3.6 (1.8–5.4) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–0.1) | 0.1 (0.0–1.7) |
| Parotids | 6.1 (0.4–15.3) | 8.2 (1.0–17.3) | 10.1 (2.0–18.8) | 11.5 (1.1–19.0) | 3.3 (1.0–7.1) | 4.3 (1.5–8.1) | 5.2 (2.1–8.7) | 6.3 (2.2–9.8) | 0.0 (0.0–0.3) | 0.3 (0.0–1.6) | 1.0 (0.0–3.8) | 3.7 (0.0–9.2) |
| Optic chiasm | 2.5 (0.2–9.1) | 4.2 (0.3–12.7) | 7.4 (0.4–20.1) | 12.8 (4.3–22.7) | 7.9 (1.5–13.9) | 9.7 (1.8–16.7) | 11.2 (1.9–18.1) | 14.2 (5.4–20.3) | 0.0 (0.0–0.2) | 0.4 (0.0–2.5) | 2.0 (0.0–9.9) | 6.5 (0.2–19.0) |
| Whole brain | 6.1 (1.8–13.1) | 7.1 (2.8–13.5) | 8.0 (3.8–13.9) | 8.7 (5.7–12.2) | 5.9 (2.7–13.0) | 6.9 (3.6–13.3) | 7.8 (4.6–13.8) | 8.6 (5.8–12.8) | 3.8 (1.2–7.9) | 4.8 (2.0–8.5) | 5.6 (2.8–9.2) | 6.8 (5.0–8.2) |
| SVZ | 0.4 (0.1–1.1) | 0.5 (0.1–1.2) | 0.7 (0.2–1.4) | 0.9 (0.5–2.1) | 1.1 (0.3–3.3) | 1.3 (0.4–4.8) | 1.5 (0.5–6.0) | 1.8 (0.6–7.5) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) |
*Hippocampal dose from 23.4 Gy whole-brain irradiation and boost treatment of 30.6 Gy.