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. 2014 Mar 17;8:9. doi: 10.3389/fnana.2014.00009

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Copyright © 2014 Salegio, Streeter, Dube, Hadaczek, Samaranch, Kells, San Sebastian, Zhai, Bringas, Xu, Forsayeth and Bankiewicz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Early distribution of micelles. (A–D) Cisternal injection of fluorescently labeled micelles (shown in green) indicate the rapid transport of these particles within different regions of the NHP brain. These micelles filled the perivascular space of blood vessels throughout the brain, particularly in the brainstem (BS), cerebellum (CB), ventral tegmental area (VTA), and amygdala (AM). Note that these micelles are shown in green (white arrows) and presence of autofluorescent lipofuscin is shown in red. Scale bars: A,D = 500 μm; B,C = 250 μm.