Table 2.

Picato Gel and Other FDA-Approved Topical Therapies for Actinic Keratoses (AKs)

Active Ingredient	Brand Name	Indications	Directions	Cost per Treatment
Imiquimod cream	Aldara 5% cream	AKs of face and scalp	Apply two times per week for 16 weeks on face or scalp	$1,023.18
Diclofenac sodium gel	Solaraze 3% gel	AKs	Apply to lesions twice daily for 60 to 90 days	$1,863.84–$2,795.76
5-Fluorouracil	Efudex 5% cream	Multiple AKs	Apply twice daily for 2 to 4 weeks	$287.50
	Fluoroplex 1% cream and solution	Multiple AKs	Apply daily for 2 to 6 weeks	Cream: $462.00 Solution: $75.61
	Carac 0.5% cream	Multiple AKs of face and anterior scalp	Apply daily for 4 weeks	$466.66
Aminolevulinic acid	Levulan Kerastick 20% solution	AKs of face and scalp	Apply on lesions 14 to 18 hours before blue light exposure	$1,285.46
Ingenol mebutate	Picato 0.015% and 0.05% gel	0.015% gel: AKs of face and scalp 0.05% gel: AKs of trunk and extremities	Apply daily to lesions for 3 days Apply daily to lesions for 2 days	$765.76 $765.76

Cost data from Red Book Online.¹⁵