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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: Biotechnol Adv. 2013 Sep 11;31(7):1047–1062. doi: 10.1016/j.biotechadv.2013.09.001

Table 2.

Comparison between population-level and single-cell analyses.

Single-cell analysis Population-level analysis
Resolution Single cell, subcellular Cell populations
Data pattern Distribution/scatter Average value, standard deviation (based on number of experimental replicates)
Dimensionality Multiple (O(10–103)a) markers can be assessed at genomic and mRNA levels, more limited (O(10)) at protein level Multiple marker (up to O(104) or higher) assessment is possible
Downstream data processing Significantly higher Lower
Required detection sensitivity Higher Lower
Instrumentation requirements High Relatively low
a

O(): order of magnitude.

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