Figure 6. Treatment of Setx and Tdp1 mice with Topotecan induces severe weight loss.

Wiltype (WT), Setx^−/− and Tdp1^−/− mice were treated with a daily dose of topotecan (TPT, 2 mg/kg/day) over a period of 9 days in order to exacerbate the formation of R-loops in these mice. Mice of each genotype were injected daily with a dose of TPT (2 mg/kg/day) and weights were recorded daily (n = 3). Controls were injected with an equivalent volume of purified water.