Figure 1. Intranasal treatment with LTS61K or LTS61K/Dermatophagoides pteronyssinus (Der p) alleviates Der p-induced allergic asthma in mice.

Mice were sensitized to and boosted with Der p mixed with incomplete adjuvant. After an initial airway challenge, intranasal treatments were given thrice in 1 week. After a second airway challenge, mice were sacrificed 3 days later and assessed for airway resistance based on (A) Penh values, (B) total infiltrated cells, and (C) cytokines in bronchoalveolar lavage fluid (BALF). (D) Hematoxylin and eosin staining. Red arrows indicate inflammatory cell infiltrates in the parenchyma and damaged epithelial cells in the bronchi. Results represent the mean ± standard error of the mean for n = 6–12 mice per group. *p<0.05, **p<0.01. Data are shown for 3 representative experiments.