Figure 1.

Relevant pathways identified for gefitinib (A), celecoxib (B), tamoxifen (C), and tretinoin (D). Yellow octagons and red circles represent the drugs and their primary targets. The orange, rose, green, and magenta squares represent relevant pathways responsible for the MOAs, biological functions, and current and potential clinical uses of drugs, respectively. Black solid lines are between a drug and the retrieved relevant pathways. Edge labels indicate numbers of target proteins and genes shared by each pathway. Red solid lines with an arrow represent a drug and its primary target. Purple dashed lines with an arrow represent that the primary targets are responsible for the MOAs or biological functions indicated by pathways. Cyan dashed lines with an arrow represent the primary targets or pathways of MOAs responsible for those indicating current or potential clinical uses.