Figure 1. Induction of hemogenesis in mouse fibroblasts and perspectives. Gata2, cFos, Gfi1b, and Etv6 were identified as sufficient to induce a hemogenic program in mouse fibroblasts. First, endothelial precursor cells are induced that generate semi-adherent cells with hematopoietic stem cell features. Future perspectives are highlighted including translation to the human system and comparison with hematopoietic stem cell specification during embryogenesis.