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Figure 1. dsRNA-binding protein warfare: STAU1 binds one class of mRNA 3′ UTR IRAlus, reducing the impact of 2 “bullets” and thereby enhancing 3′ UTR IRAlus gene expression. STAU1 is shown as a bulletproof vest. Bullet #1 is p54nrb, which inhibits 3′ UTR IRAlus mRNA nuclear export. Bullet #2 is PKR, which inhibits 3′ UTR IRAlus mRNA translation and, less so, global-cell translation.
