Figure 6. Combination of rapamycin and resveratrol strongly reduces the survival of Tsc2-null cells in vivo. Mice were treated with vehicle, rapamycin, resveratrol, or rapamycin plus resveratrol. ELT3-luciferase-expressing cells were inoculated intravenously. (A) Representative bioluminescent images of cells after each drug treatment were shown. The total flux (photons/second) of cells was illustrated. (B) Representative bioluminescent images of lung colonization at 1, 6, and 24 h post-cell injection. Total photon flux/second present in the chest regions were quantified and compared among treatment groups. *P < 0.05, **P < 0.01, Student t test.