. 2014 Feb 24;2014:947946. doi: 10.1155/2014/947946

Table 1.

The metabolic profile of leonurine in various rat biological samples.

Biological sample	Mean percentage of metabolites against total counts (%)^a				Total peak areas (counts)^b
Biological sample	M1	M2	M3	M0 (Parent)	Total peak areas (counts)^b
Plasma^c	94.59	0.70	N.D.	4.71	3.30 × 10⁶
Bile^d	80.38	1.84	0.28	17.50	5.49 × 10⁷
Urine^e	77.90	0.21	0.08	21.81	2.79 × 10⁷
Feces^e	N.D.	N.D.	1.73	98.27	1.70 × 10⁷

N.D.: not detected.

^aCalculated as (peak area of each compound/total peak areas of all compounds) × 100.

^bThe peak areas of parent and each metabolite were obtained under MRM scan mode.

^cThe pooled plasma samples collected from 6 rats after oral dosing of leonurine.

^dThe 0–8 h bile samples collected from 6 bile duct-cannulated rats after oral dosing.

^eThe 0–16 h samples collected from 6 rats after oral dosing.