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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: J Am Chem Soc. 2013 Dec 31;136(2):733–740. doi: 10.1021/ja410437d

Figure 1.

Figure 1

Microfluidic mixing device. A. Photograph of PEEK chip (25×25 mm2) showing laser microfabricated surface features, including mixing regions M1 through M5 and access channels. B. Schematic of an expanded region (circled in A) covering mixing regions M1 through M3. PB: high-pH pulse buffer in H2O; UP: unfolded protein in D2O; QB: low-pH quench buffer in H2O. C. Photograph of the steel holder containing the multi-mixer chip illustrated in A. D. Calibration of the mixing device using alkaline hydrolysis of phenol chloroacetate (PCA; inset). The absorbance of the product (phenol) was measured at 270 nm vs. aging time.