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. Author manuscript; available in PMC: 2014 Mar 17.
Published in final edited form as: J Nucl Med. 2012 Jun 5;53(7):1119–1126. doi: 10.2967/jnumed.112.103465

FIGURE 3.

FIGURE 3

Female WT mice with SSM3 tumors in right thoracic mammary fat pad were treated with 50 μg of intra-peritoneal letrozole daily for 2 d (n = 4) or were left untreated (n = 4). After baseline imaging, mice pretreated with letrozole were subsequently administered 20 μg of subcutaneous estradiol. 18F-FFNP small-animal PET of untreated mice (−) and mice treated with letrozole followed by estradiol (Let-E2) was performed 24 h later. Activity was measured in tumor and muscle. Coronal fused 3-dimensional PET/CT images and quantification are shown. **P < 0.01.