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. 2014 Mar 17;9(3):e90710. doi: 10.1371/journal.pone.0090710

Table 2. Prevalence of mutations from the WHO transmitted drug resistance surveillance list.

NRTI mutations NNRTI mutations PI mutations
Mutation N (Pv, %) Mutation n (Pv, %) Mutation n (Pv, %)
M41L 32 (1.15) L100I 2 (0.07) L24I 2 (0.07)
K65R 1 (0.04) K101EP 8 (0.29) D30N 1 (0.04)
D67EGN 23 (0.83) K103N/S 77 (2.77) V32I 2 (0.07)
T69D 5 (0.18) Y181CIV 9 (0.32) M46IL 26 (0.93)
K70ER 5 (0.18) Y188CHL 5 (0.18) I47AV 2 (0.07)
L74IV 3 (0.11) G190AES 11 (0.40) F53LY 2 (0.07)
F77L 2 (0.07) P225H 3 (0.11) I54ALMSTV 2 (0.07)
Y115F 2 (0.07) M230L 1 (0.04) V82ACFLMST 5 (0.18)
M184IV 13 (0.47) N83D 1 (0.04)
L210W 12 (0.43) I85V 1 (0.04)
T215REV* 37 (1.33) N88DS 2 (0.07)
T215YF 2 (0.07) L90M 10 (0.36)
K219EQNR 29 (1.04)
1 mut. 56 (2.01) 1 mut. 87 (3.13) 1 mut. 45 (1.62)
2 mut. 32 (1.15) 2 mut. 13 (0.47) 2 mut. 2 (0.07)
≥3 mut. 13 (0.47) ≥3 mut. 2 (0.07) ≥3 mut. 1 (0.04)
Prevalence (95%CI) 3.6 (2.9–4.3) Prevalence (95%CI) 3.7 (3.0–4.4) Prevalence (95%CI) 1.7 (1.2–2.2)

NRTI: nucleoside reverse transcriptase inhibitors; NNRTI: non-nucleoside reverse transcriptase inhibitors; PI: protease inhibitors; Pv: prevalence; mut.:mutation. Amino acide abbreviations: A, alanine; C, cysteine; D, aspartate; E, glutamate; F, phenylalanine; G, glycine; H, histidine; I, isoleucine; K, lysine; L, leucine; M methionine; N, asparagine; P, proline; Q, glutamine; R, arginine; S, serine; T, threonine; V, valine; W, tryptophan; Y, tyrosine. * = C/D/E/N/I/V/S.