Table 2.

Mean change from baseline and week 12 in MMSE score, TPC score, Digit Span Test score, and VFT score, and serum BDNF level in patients with vascular dementia stratified by treatment group

	Week 12		Mean change from baseline to week 12
	Fluoxetine mean (SD)	Control Mean (SD)	Fluoxetine mean (SD)	Control mean (SD)	P-value
MMSE	16.1 (2.9)	15.8 (2.7)	1.0 (1.2)	0.2 (1.4)	0.031
TPC	4.5 (1.4)	4.3 (1.2)	0.8 (0.9)	0.2 (0.9)	0.007
Digit Span	5.0 (1.3)	5.1 (0.9)	0.4 (0.9)	0.2 (1.0)	0.342
VFT	15.0 (5.2)	16.2 (4.1)	0.3 (2.2)	0.5 (2.1)	0.660
BDNF (ng/ml)	25.7 (4.0)	21.5 (6.9)	4.5 (3.7)	0.1 (3.2)	<0.0001

Abbreviations: BDNF, brain-derived neurotrophic factor; MMSE, Mini-Mental State Examination; SD, standard deviation; TPC, Ten-Point Clock Drawing; VFT, Verbal Fluency Test.