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. 2014 Mar 17;9(3):e91569. doi: 10.1371/journal.pone.0091569

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© 2014 Gupta et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Heat map showing predicted pathways for the miRNAs that were differentially modulated in LX2 cells treated with supernatants from (A) R5-tropic or (B) X4-tropic HIV-1 infected PBMCs. DIANA miRPath v2.0 was used to predict the pathways with default p-value threshold of 0.05 and microT threshold of 0.8. This clustering is based on significance analysis. All significantly targeted pathways are marked with deep red. On the vertical axis, miRNAs are clustered together by exhibiting similar pathway targeting patterns.