(A) Seated MAP, (B) standing MAP, (C) seated DBP, and (D) standing DBP profiles for placebo vs. sertraline 50mg are presented with BP measurements at baseline and at hour intervals for 4 hours after administration. Solid circles represent sertraline values while open boxes represent placebo values. P-value of paired samples t-test (2 tailed) for blood pressures at 4 hours between placebo and sertraline are shown. Repeated measures analysis of variance P values are also presented for the overall effect of the study drug over time (Pdrug).
MAP: mean arterial pressure; DBP: diastolic blood pressure