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. 2014 Mar 17;9(3):e91351. doi: 10.1371/journal.pone.0091351

Figure 1. Editing events in the human OPHN1 transcript.

Figure 1

(A) Sequence of an intronic portion of OPHN1 pre-mRNA (intron 9–10), with AluJo region in blue and adenosines undergoing editing in red capital letters. In grey, primers used for PCR amplifications (AluJo Fw and AluJo Rev, Table S1, see File S1). (B) Chromatogram of the AluJo region isolated from human brain cDNA, showing the newly identified editing sites, named as 1 to 14 and represented as a double peak of adenosine (green) and guanosine (black). The same positions (1–14) in the corresponding human brain gDNA sequence are only adenosine (Figure S1 in File S1).