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Experimental protocol is shown. ApoE KO mice placed on a high-fat diet (HFD) for 12 weeks were divided into four groups: i) control (HFD only); ii) HFD + irbesartan (5 mg/kg/day); iii) HFD + irbesartan + GW9662, a PPARγ antagonist (0.5 mg/kg/day) and iv) HFD + irbesartan + neutralizing antibody against HGF (200 μg/week). ApoE, apolipoprotein E; KO, knockout; PPARγ; peroxisome proliferators activated receptor-γ.
