Table I.
Serum parameters in each group.
| Parameter | Irbesartan
|
|||
|---|---|---|---|---|
| Control | (−) | GW9662 | HGF-Ab | |
| AST (U/l) | 182.0±10.3 | 133.3±5.7a | 168.8±5.7b | 161.5±4.8b |
| ALT (U/l) | 30.5±2.3 | 29.6±1.7 | 30.9±2.5 | 31.4±2.9 |
| LDL-chol (mg/dl) | 1034±56 | 925±16 | 991±73 | 1006±29 |
| T-chol (mg/dl) | 1248±21 | 1069±48 | 1095±89 | 1194±47 |
| FFA (mEq/l) | 1.58±0.19 | 1.13±0.02a | 1.29±0.05 | 1.43±0.08b |
| HDL-chol (mg/dl) | 62.2±3.7 | 88.2±4.4a | 58.0±5.7a | 66.3±6.6 |
a
P<0.05 vs. control.
b
P<0.05 vs. irbesartan only. Data are shown as the mean ± standard error of the mean. HGF-Ab, hepatocyte growth factor neutralizing antibody; AST, aspartate transaminase; ALT, alanine aminotransferase; LDL-chol, low-density lipoprotein cholesterol; T-chol, total cholesterol; FFA, free fatty acid; HDL-chol, high-density lipoprotein cholesterol.