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. 2014 Mar 11;9:1311–1322. doi: 10.2147/IJN.S59726

Figure 6.

Figure 6

Protection of OTMCS-PEI-R13 on plasmid DNA. (A) Protection of plasmid DNA from degradation by DNase I concentrations of 0, 9, 10.5, 12, 13.5, 15, 16.5, 18, 19.5, 21, and 23.5/μg DNA. (B) Protection of plasmid DNA from dissociation by serum at varying concentrations of 10%, 25%, and 50%. The lanes 10%, 25%, and 50% without “+” refer to the presence of only 10%, 25%, and 50% serum; the lanes 10%, 25%, and 50% with “+” refer to the presence of OTMCS-PEI-R13/DNA complex at a w/w ratio of 20 with different concentrations of serum. (C) Protection of plasmid DNA from dissociation by sodium heparin at varying concentrations of 0, 120, 160, 200, 240, 280, 300, 400, 500, and 600 μg/mL.

Abbreviations: OTMCS, N-octyl-N-quaternary chitosan; PEI, polyethylenimine; R13, RGDC-TAT (49–57); w/w, weight/weight.