Fig 10.

Co-infected TLR2^−/− mice display reduced pathology.A and B. Wild type and TLR2^−/− mice were infected with C. albicans or the combination of C. albicans and S. oralis for 5 days and tongue lesions were digitally photographed (A) and graded for pathology (B) as described in the materials and methods. Median values of pathology scores in each infection group is designated by horizontal lines. Each dot represents an individual mouse with 8–12 mice per group. Lesion scores in TLR2^−/− animals co-infected with C. albicans and S. oralis were significantly lower than in wild type animals (P = 0.039).C. Body weight loss in TLR2^−/− and wild type animals during the five day infection period, expressed as percentage of initial weight (day 1). Error bars represent SEM. *P = 0.04 for a comparison between TLR2^−/− and WT animals.