Table 2.
Substance | Effect of Combination with ARVs |
---|---|
Cannabis | Combination with efavirenz may heighten the euphoria of cannabis by CYP3A4 inhibition |
Cocaine | No known effect in combination with ARVs |
Heroin | No known effect in combination with ARVs |
Oxycodone | Enhanced effect in combination with ritonavir by CYP2D6 inhibition |
Methadone | Opiate withdrawal in combination with efavirenz or nevirapine by CYP3A4 induction |
MDMA | Enhanced effect of MDMA in combination with ritonavir by CYP2D6 inhibition |
Ketamine | Enhanced psychogenic effect of ketamine in combination with efavirenz and ritonavir by CYP2B6 inhibition |
PCP | Enhanced psychogenic effect of PCP in combination with efavirenz or ritonavir by CYP3A4 inhibition |