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. 2014 Mar 11;9:1323–1337. doi: 10.2147/IJN.S51535

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© 2014 Rizvi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Fixed cell imaging of HER2 receptors in SK-BR-3 (A–C) and MCF7 (D and E) cell lines. (A) Control SK-BR-3 and (B) SK-BR-3 cells exposed to QD-anti-HER2-antibody. (C) Magnified inset of (B) showing ring-like fluorescence of QDs on the cell surface. (D) Control MCF7 and (E) MCF7 exposed to the QD-antiHER2-antibody bioconjugate.

Note: HER2-overexpressing cells show significantly higher fluorescence as the QD-antibody probe binds to the cell surface (B). Arrow demonstrates magnified inset of image B in image C. In contrast, MCF7 have lower expression of HER2 and show minimal fluorescence.

Abbreviations: HER2, human epidermal growth factor receptor 2; QDs, quantum dots.