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. 2014 Mar 17;9(3):e91790. doi: 10.1371/journal.pone.0091790

Table 3. Significant associations (P<0.05) of reported-T2D loci with quantitative glycemic traits in controls of the DMS case-control sample.

Fasting glucose OGTT 2-h glucose Fasting insulinb
(mmol) (mmol/l) (pmol/l) HOMA_IRb HOMA_Bb Insulinogenic indexb
SNP Nearby gene Effect allelea β (SE) P-value β (SE) P-value β (SE) P-value β (SE) P-value β (SE) P-value β (SE) P-value
rs780094 GCKR G 0.02 (0.01) 0.07 0.03 (0.02) 0.17 0.01 (0.01) 0.43 0.01 (0.01) 0.21 −0.01 (0.01) 0.52 0.05 (0.02) 0.047
rs243021 BCL11A c T 0.02 (0.01) 0.055 −0.03 (0.02) 0.24 0.02 (0.01) 0.08 0.02 (0.01) 0.03 0 (0.01) 0.91 0.02 (0.03) 0.41
rs4607103 ADAMTS9 c C 0.01 (0.01) 0.25 0.02 (0.02) 0.45 0 (0.01) 0.67 0.01 (0.01) 0.56 0 (0.01) 0.95 −0.07 (0.02) 5.33×10−3
rs7756992 CDKAL1 G 0.02 (0.01) 0.09 0.04 (0.02) 0.055 −0.01 (0.01) 0.21 −0.01 (0.01) 0.37 −0.02 (0.01) 0.12 −0.07 (0.02) 6.21×10−3
rs896854 TP53INP1 A 0.01 (0.01) 0.20 −0.01 (0.02) 0.65 −0.03 (0.01) 0.01 −0.02 (0.01) 0.03 −0.03 (0.01) 0.04 −0.03 (0.03) 0.32
rs10811661 CDKN2A/B c T 0.01 (0.01) 0.49 0.06 (0.02) 9.11×10−3 0 (0.01) 0.96 0 (0.01) 0.78 −0.01 (0.01) 0.53 −0.05 (0.02) 0.03
rs13292136 CHCHD9 c C −0.02 (0.02) 0.42 −0.08 (0.04) 0.03 −0.02 (0.02) 0.32 −0.02 (0.02) 0.28 −0.01 (0.02) 0.78 −0.04 (0.04) 0.33
rs12779790 CDC123 c G 0.01 (0.01) 0.60 0.02 (0.03) 0.42 0.03 (0.01) 8.58×10−3 0.04 (0.01) 9.39×10−3 0.02 (0.02) 0.18 0 (0.03) 0.99
rs1111875 HHEX c G −0.02 (0.01) 0.12 −0.01 (0.03) 0.79 −0.01 (0.01) 0.29 −0.02 (0.01) 0.17 0.01 (0.02) 0.71 −0.09 (0.03) 6.73×10−4
rs7903146 TCF7L2 T 0.03 (0.03) 0.34 0.17 (0.06) 4.90×10−3 0.03 (0.03) 0.26 0.03 (0.03) 0.24 0.02 (0.04) 0.48 −0.01 (0.06) 0.87
rs10830963 MTNR1B G 0.03 (0.01) 5.50×10−3 0 (0.02) 0.86 0 (0.01) 0.83 0.01 (0.01) 0.43 −0.02 (0.01) 0.16 −0.02 (0.02) 0.43
rs11634397 ZFAND6 c G −0.03 (0.02) 0.12 −0.05 (0.04) 0.21 0 (0.02) 0.78 0 (0.02) 0.97 0.03 (0.02) 0.15 −0.11 (0.04) 4.67×10−3
rs9939609 FTO A −0.01 (0.02) 0.75 0 (0.04) 0.90 −0.04 (0.02) 0.02 −0.04 (0.02) 0.02 −0.02 (0.02) 0.33 0.01 (0.04) 0.73

P-values <0.05 are shown in bold.

a

Previously reported risk alleles.

b

Log-transformed values were used in general linear regression models.

c

The nearest gene is provided if a SNP is intergenic.

HOMA-B, homoeostasis model assessment of beta-cell function; HOMA-IR, homoeostasis model assessment of insulin resistance; OGTT, oral glucose tolerance test; SE, standard error; SNP, single nucleotide polymorphism.