. 2014 Mar 17;9(3):e91644. doi: 10.1371/journal.pone.0091644

Table 2. Univariate and multivariate analyses for the correlation of clinicopathological variables and ribonucleotide reductase M2 (RRM2) with survival.

	Case number	Mean (median) survival month	5-year survival rate (%)	Hazard ratio	95% confidence interval	p value
Univariate analysis
Age (years old)^a
≤50	56	109 (133)	79.1	1	Reference	0.25
>50	45	90 (110)	81.7	1.60	0.72–3.57
Stage^a
I	67	107 (133)	84.8	1	Reference	0.26
others	34	88 (119)	72.5	1.58	0.71–3.54
Pathologic type^a
squamous cell carcinoma	81	104 (132)	83.8	1	Reference	0.32
adenocarcinoma	20	95 (133)	67.1	1.59	0.63–4.00
Depth of stromal invasion^a
≤1/2 depth	43	124 (133)	94.9	1	Reference	0.0004
>1/2 depth	57	82 (110)	70.1	6.90	2.03–23.26
Tumor diameter^a
≤4 cm	70	111 (133)	89.1	1	Reference	0.013
>4 cm	27	74 (105)	63.6	2.84	1.20–6.76
Tumor grade^a
well	17	126 (133)	93.8	1	Reference	0.072
moderate and poor	68	92 (115)	77.5	5.21	0.69–38.46
Parametrial invasion^a
no invasion	78	109 (133)	85.7	1	Reference	0.0091
invasion	23	72 (109)	64.2	2.94	1.25–6.90
Vagina invasion^a
no invasion	86	104 (133)	80.8	1	Reference	0.57
invasion	15	89 (110)	79.4	1.32	0.49–3.56
Pelvic lymph node metastasis^a
negative	82	107 (133)	84.3	1	Reference	0.037
positive	19	78 (119)	64.1	2.39	1.03–5.56
RRM2^a
negative	22	126 (132)	95.5	1	Reference	0.016
positive	79	96 (115)	76.4	7.94	1.07–58.82
Multivariate analysis
Depth of stromal invasion^a
≤1/2 depth	43	124 (133)	94.9	1	Reference	0.015
>1/2 depth	57	82 (110)	70.1	6.25	1.43–27.03

Statistical analysis: Kaplan-Meier products limit method and multivariate and univariate Cox regression models.

Some clinicopathological data could not be collected from the patients with cervical cancer due to incomplete medical charts or records.