Table 2.

Detailed information of selected gene batteries in liver and muscle.

NO.	FUNCTIONS	LIVER		MUSCLE
		PATTERNS	GENES	PATTERNS	GENES
1	Adherens junction	7	actn1, ctnna1, iqgap1, ptprm, rac2	2	actn3, ctnnb1, fyn, iqgap1, loc679869, met, ptprf, ptprm, pvrl2, rac1
2	Aminoacyl-tRNA biosynthesis	5	aars, eprs, farsa, farsb, mars2, tars, wars, yars	1	cars, gars, kars, lars, mars, nars, qars, sars, tars
3	ECM-receptor interaction	7	cd47, col1a2, col3a1, lamc1, reln	2	chad, col1a1, col1a2, col3a1, col4a1, col5a1, col5a2, col5a3, col6a1, col6a2, fn1, itgb1, lamb1, lamc1, tnc
4	Focal adhesion	7	actn1, ccnd1, col1a2, col3a1, igf1, lamc1, rac2, rap1b, reln	2	actn3, cav3, chad, col1a1, col1a2, col3a1, col4a1, col5a1, col5a2, col5a3, col6a1, col6a2, ctnnb1, egf, fn1, fyn, hras, itgb1, lamb1, lamc1, met, mylpf, pak1, pdgfa, ppp1r12a, prkcb, rac1, tnc
				3	grb2, igf1, map2k1, ik3cd, vwf
5	Insulin signaling pathway	6	eif4ebp1, fasn, fbp1, mtor, ppp1r3b, ppp1r3c	2	calm3, fbp2, flot1, fot2, hras, phka1, phkg1, prkaa2, prkab2, prkar1a, prkci, ptprf, rhoq,sh2b2
6	Lysosome	11	acp2, ctsh, dnase2b, fuca1, glb1, hexa, lamp2	1	acp2, ap1 m1, ap3b1, ap3d1, atp6v0a1, atp6v0d1, cln5, cltb, ctsf, ctsl1, gaa, gga1, lgmn
7	MAPK signaling pathway	3	cdc42, gadd45a, il1r, kras, map2k1ip1, mapk14, max, pla2 g12a, srf, tp53	2	cacna2d1, cacng1, dusp14, dusp6, egf, evi1, hras, map2k6, pak1, pdgfa, ppp3ca, ppp3cb, ppp3r1, prkcb, rac1, rasa1, srf, tgfb2
8	Neurotrophin signaling pathway	5	akt1, arhgdia, bad, rac1, tp53, ywhae, ywhag, ywhah, ywhaz	2	calm3, camk2a, camk2d, camk2 g, hras, maged1, pdk1, rac1, sh2b2, ywhaq, ywhaz
9	Cell cycle relevant-processes	5	ppp2r1a, ppp2r5a, rbx1, ywhae, ywhag, ywhah, ywhaz	2	anapc1, calm3, camk2a, camk2d, camk2 g, ccnb2, cdc2, espl1, itpr1, ppp2r5a, ppp2r5c, ppp3ca, ppp3cb, ppp3r1, slk, ywhaq, ywhaz
		6	atp5e, atp5l, cox6a1, cox8a, ndufa1, ndufb6, ndufs5, ndufs6, ndufv2, ndufv3, sdhd, uqcr, uqcrq
10	Oxidative phosphorylation	11	atp5a1, atp5c1, atp5i, atp5o, cox6c, cox7a2, cox7b, ndufa11, ndufa2, ndufa4, ndufa6	5	atp5 j, cox5a, cox7a2, ndufb2, uqcrh
		8	atp5f1, atp5h, cox4i1, cox5b, sdhc, ndufa3, ndufb4, ndufb7, ndufb9
11	Pentose phosphate pathway	6	aldob, fbp1, gpi, pgls, pgm1	2	fbp2, g6pd, gpi, pfkp, pgm1
12	PPAR signaling pathway	12	acaa1, acox2, acsl1, apoa1, scp2	1	acadl, acox1, acsl4, cpt1b, cpt2, ehhadh, nr1h3, slc27a1
13	Proteasome	5	psma3, psma5, psmb1, psmb2, psmc4, psmd13, psmd3, psmd4, psmd8	1	psma1, psma2, psma3, psma4, psma5, psma7, psmb2, psmb3, psmb4, psmb7, psmc1, psmc2, psmc4, psmc5, psmd11, psmd13, psmd1, psmd3, psmd4, psmd6, psmd7, psmd8
14	Purine metabolism	5	adsl, ak2, gart, guk1, nt5c3, pole4, polr3d, prps2	1	adcy2, ampd3, impdh2, pde2a, pde4b, pold4, polr1a, polr1b, polr1c, polr1e, polr2e, polr2f
15	Spliceosome	3	bat1, hnrnpa1, hnrnpk, lsm5, pcbp1, magoh, nhp2l1, plrg, prpf19, rbm17, rbm8, sf3b2, sf3b4, sfrs1, snrpb	1	bud31, cherp, cwc15, hnrnpu, ncbp1, pcbp1, prpf3, prpf6, sart1, thoc1, usp39, wbp11
		5	dhx15, eftud2, hnrnpc, lsm7, lsm8, prpf8, smndc1, snrpe
16	Tight junction	3	cdc42, kras, ppp2ca, ppp2cb, spna2, vapa	2	actn3, amotl1, cldn5, ctnnb1, cttn, epb4.1l2, exoc4, f11r, hras, myh3, mylpf, prkcb, prkci
		7	actn1, amotl1, cldn3, ctnna1, exoc3, ocln, rras2
17	Ubiquitin mediated proteolysis	3	prpf19, uba2, ube2d3, ube2g2, ube2 j2, ube2n, ube2 s, vhl	1	anapc7, birc3, herc4, keap1, klhl9, pias4, ube2d3, ube2 g1, ube2 j1, ube2l3, ube4a
		5	cdc34, rbx1, rchy1, syvn1, ube2d3, ube2e3, ube2f, ube2 j1
18	Wnt signaling pathway	3	ppp2ca, ppp2cb, psen1, ruvbl1, senp2, smad4, tp53	2	camk2a, camk2d, camk2 g, ctnnb1, ctnnbip1, daam1, loc679869, ppp2r5a, ppp2r5c, ppp3ca, ppp3cb, ppp3r1, prkcb, rac1

Notes: ⁺genes shown in bold type are those whose promoters contain GRE (Glucocorticoid Receptor Element) binding sites. Details are listed in supplemental material 2.