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. 2014 Mar 17;9(3):e92064. doi: 10.1371/journal.pone.0092064

Figure 6. Agonist binding pocket and additional ligands for MOR42-3.

Figure 6

A. α-hexyl cinnamaldehyde docked in MOR42-3. Ligand binding pocket is colored by binding property with green representing hydrophobic areas, red hydrogen bond acceptors and blue hydrogen bond donors. Hydrogen bond between carbonyl oxygen from α-hexyl cinnamaldehyde (ranked 17, Table 1 ) and guanidinuim group of arginine 179 (R179) is presented with an interatomic distance of 1.57Å. B. Residues within 5Å distance from the best docking conformation of α-hexyl cinnamaldehyde. C. Structural relatives of α-hexyl cinnamaldehyde and their responses. Oocytes expressing MOR42-3, Gαolf and CFTR were screened with 15 sec application of 100 μM indicated odorants. Responses were normalized to the average 100 μM NDA-evoked responses and results are presented as a mean±SEM, n =  5–10.